[Ontogenetic characteristics of patients with erectile dysfunction with different types of aging.]

Age-related erectile dysfunction (ED) can be formed during ontogenesis in accordance with various mechanisms of the pathogenesis of aging in conjunction with a particular cluster of diseases. The aim of the work is to study ontogenetic features of ED patients in late ontogeny of various types of aging. 65 men over 45 with an explicit form of ED were examined. The first group consisted of patients with general-somatic diseases (GSD) arising mainly from the accumulation model of aging, and the second group included patients with age-associated diseases (AAD), arising primarily from the ontogenetic model of aging. Both variants of age-related ED are closely related to ontogenetic events, especially with the debut of obesity and the loss of morning erections, preceding the ED debut, on average over a decade of life. ED, combined with AAD, is most clinically and pathogenetically compromised. Thus, it is characterized by: earlier age of debut ED, dismetabolic pattern, low geroprotective pattern, poor quality of primary health, pronounced instability of gonadostat, weak sexual constitution, decreased sensitivity of hypothalamic-pituitary complex to feedback signals, the large proliferative pattern. ED associated with GSD had a later age of debut ED, developed much later from the debut of obesity, had a lower level of testicular volume with a more conserved incretory function, but a higher index of IPSS. Thus, the separation of two ED variants associated with different types of aging in conjunction with the use of ontogenetic analysis, allowed to identify significant differences in such clinical and pathogenetic forms, which is important for the development of ideas about the diagnosis and treatment of age-related ED.

[Prognosis of the hemorrhage recurrence in the patients suffering from acute gastroduodenal ulcer bleeding].

The prognostication method for the hemorrhage recurrence, permitting to estimate the risk of its occurrence and to prescribe an adequate antirecurrence treatment, was proposed. Among numerous predictors of recurrence the most significant clinical, endoscopic and laboratory factors were selected to raise the prognostication precision. Depending on therisk degree of a recurrent hemorrhage, different methods of treatment were prescribed to the patients. The proposed method was applied in 112 patients, suffering ulcer gastroduodenal hemorrhage. The hemorrhage recurrence have had occurred in 45 (43.3%) of them, in 5 (4.46%)--operative intervention was conducted, using organpreserving methods. General lethality have had constituted 0.89%, postoperative one in a control group--7.14%, and in the main all the patients were alive. The method proposed permits with a high precision to prognosticate and to determine effective tactics of treatment. Taking into account the additional factors of risk raises the prognosis precision and permits to prescribe antihelicobacter therapy and the proton pump inhibirors in a rational dosage soundly.

[Treatment strategy for ulcerative gastrointestinal bleeding from the upper gastrointestinal tract].

The deep statistical analysis of patients treatment with the ulcerous gastroduodenal bleeding set 2 years works of Center of the gastroduodenal bleeding of Dnepropetrovsk is conducted. It is exposed, that wide application of methods of endoscopic haemostasis and endoscopic monitoring allowed substantially to reduce the amount of operations at this category of patients and improve the results.

[Rational antibacterial therapy of acute surgical diseases of abdominal organs].

Comparative analysis of medical documents, concerning 1055 patients, aged 18-92 yrs old, operated for an acute surgical diseases of abdominal organs in 2007-2009 yrs, was performed. Preoperative antibioticotherapy was performed in all the patients, in 877 of them ceftazidim (ceftadim) was administered as the main antibacterial preparation and in 178--other antibacterial preparations. Application of ceftadim, as a basic preparation in antibioticotherapy, had permitted to lower the purulent-septic complications rate by 61% and to reduce the stationary treatment duration of the patients.

[An experimental validation of the use of various types of allografts for the replacement of mandibular defects]. / Eksperimental'noe obosnovanie primeneniia razlichnykh vidov allotransplantatov dlia zameshcheniia defektov nizhnei cheliusti.

The intensity of restructuring of various types of bone transplants and reaction of the adjacent tissues of the femoral distal epiphysis to these transplants was studied in rat experiments. The most manifest bone-inducing properties were detected in demineralized allobone, the least so in formalin-treated one; lyophilized and frozen transplants occupy an intermediate position between these two. These data are recommended to be borne in mind when replacing mandibular defects.

[Changes in the mouth mucosa during local UHF-hyperthermia and radiotherapy of malignant tumors of the maxillofacial region]. / Izmeneniia slizistoi obolochki rta pri lokal'noi SVCh-gipertermii i luchevoi terapii zlokachestvennykh opukholei cheliustno-litsevoi oblasti.

Morphological investigations under experimental conditions have demonstrated that local UHF-hyperthermia at 42-43 degrees C for 30 min does not cause alterative changes of the oral mucosa in animals. The revealed signs of activization of metabolic processes can probably increase radiosensitivity of tumors and their reparation. A favorable course of radiation mucositis was noted after experimental local hyperthermia and irradiation. Morphological changes of the oral mucosa, determined mainly by exposure to radiation, are characterized in the early period by alternative and dystrophic changes, and later on (in 3 mos.) by atrophy and sclerosis. In patients local UHF-hyperthermia had a radiosensitizing effect on the oral mucosa at 40-41,5 degrees C for 30 and 60 min. However it did not prevent the completion of a radical split course in the regimen of dynamic dose fractionation nor did it increase the number of postradiation complications. Under this temperature-time regimen the time of development and a degree of expression of radiation reactions did not depend on the succession of hyperthermia and irradiation, and the time of heating.

[Therapeutic effect of a saline solution with sodium lactate (lactasol) in traumatic shock]. / Lechebnyi éffekt solevogo rastvora s laktatom natriia (laktasola) pri travmaticheskom shoke.

Acute experiments on 67 adult dogs have demonstrated that infusions of lactasol in a dose of 25 ml/kg in the early period and in a dose of 50 ml/kg in the late period of shock are not efficacious enough. Injection of the increased amount of the saline in the early and late period of shock (up to 50 and up to 100 ml/kg, respectively) makes it possible to save from death almost all the animals. A conclusion is made that the therapeutic effect of lactasol depends on the amount of the saline injected and on the period of shock during which the saline is injected, as well as on the specific action of sodium lactate.